Spike, Rarity and others in “Unfinished Business”

Spike

It's a stone scale. It isn't magical or anything like the call of the Dragon Lord. It's just... red. And itchy. [groans] And embarrassing.

Ooh, precious pants, that does look uncomfortable. But even I get the odd blemish from time to time. It's nothing to be embarrassed by. You could pay Zecora a visit. She makes a cream that works wonders. Just don't get the shampoo.

Twilight Sparkle

I used to get terrible breakouts any time I had a final exam with Celestia. Who probably never had a blemish her whole life.