Peter Gallagher - Sandy Cohen
Kelly Rowan - Kirsten Cohen
Benjamin McKenzie - Ryan Atwood
Mischa Barton - Marissa Cooper (2003-2006)
Adam Brody - Seth Cohen
Chris Carmack - Luke Ward (2003-2004)
Melinda Clarke - Julie Cooper
Rachel Bilson - Summer Roberts
Alan Dale - Caleb Nichol (2004-2005)
Tate Donovan - Jimmy Cooper (2003-2005)
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