“Hope For The Hopeless” quotes from Grey's Anatomy

Meredith

[voiceover] There's nothing else we can do for you. These are the last words a surgeon wants to tell a patient. Giving up doesn't come easy to us, so we do everything in our power not to. For surgeons "lost cause" just means..."try a little harder".

Bailey

[to Meredith] You want to waste your talent playing with one little predictable organ for the rest of your life? Nah, I'd rather spend my days leaping from the liver to the pancreas to the stomach to the bowel, and any one could go wrong at anytime. There's nothing wrong with knowing one organ and knowing it well, just like there's nothing wrong with being fifth-chair viola in the back of the orchestra. But it's a hell of a lot more fun being the conductor.

Derek

They're not called lost causes because they're fun.

Lexie

I don't need them to be fun. I just need them to not be like today.

Derek

Ok. Let's flip.

Lexie

Ugh.

Derek

Heads, you keep doing lost causes. Tails, you can do the fun stuff.

Webber

Bailey says you're declaring general.

Meredith

Actually, I'm not sure anymore.

Webber

Oh. Oh, I thought it was a done deal. I mean, it makes sense since you're––

Meredith

Because of my mother. I know. Don't you mention her, too. That's all anyone ever says it's in my blood, it's my legacy. That's why I don't want to do it. I don't want to be like my mother.

Webber

Meredith, look at everything you did today this party for your daughter, what you did for me in that O.R. You don't have to ever worry about being anything like your mother. I knew her, and you're nothing like your mother. You have a gift. Don't waste it.

Meredith

[voiceover] When do you throw in the towel? Admit that a lost cause it's sometimes just that? There comes a point when it all becomes too much. When we get too tired to fight anymore. So we give up. That's when the real work begins. To find hope where there seems to be absolutely none at all.